VAISALA POLARIS – ONLINE CONCENTRATION MEASUREMENT SOLUTION FOR THE PHARMACEUTICAL AND BIOTECHNOLOGY INDUSTRIES

Thursday May 21st, 2026
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Drug development and manufacturing is highly regulated to ensure safety, efficacy, and quality. An important initiative to boost innovation and support efficiency is the Process Analytical Technology (PAT) by the FDA. It is a framework for innovative pharmaceutical development, manufacturing, and quality assurance. PAT encourages using the latest scientific advantages and technology in pharmaceutical manufacturing as well as continuous, real-time quality assurance during processing. Continuous manufacturing (CM) is the new industry trend with many identified benefits over traditional batch-based manufacturing. Successfully implementing PAT or CM requires real-time sensors and measurement equipment.

Vaisala Polaris Process Refractometer is suitable for pharmaceutical and biotechnology processes offering reliable, continuous inline concentration measurements for a wide range of applications, such as Active Pharmaceutical Ingredients (API), vitamins, herbal-based medicine, vaccines, penicillin as well as medical protective wear, wound dressings, and medical implants manufacturing.

Quality, safety and efficacy by design

The reliable measurement and data provided by the Vaisala Polaris process refractometer help to understand critical process parameters (CPP), process conditions, and elevate process understanding and fully supports continuous manufacturing. Importantly, this refractometer can help to meet the regulatory requirements for validating, quality, and controlling the manufacturing processes.

In addition, continuous in-line measurements, and provided data help to reduce production cycle times, increase production capability, prevent rejects, abolish human errors in manufacturing and provide high quality and safe products with minimum variability. In drug manufacturing, this technological innovation can be used from laboratory-scale to pilot batches that are used in process development to the production-scale batches needed to support commercialization. In the R&D phase, using the Vaisala Polaris process refractometer can reduce drug development time.

Continuous and accurate inline measurements

Vaisala Polaris process refractometers provide continuous and accurate, reliable, repeatable, and reproducible measurements for applications aligned with Process Analytical Technology (PAT) manufacturing methods.

  • Real-time process data via Ethernet – Enables monitoring data for each batch or lot.
  • Supports cGMP compliance – Helps ensure manufacturing meets Current Good Manufacturing Practice standards.
  • Traceable calibration and verification – Ensures measurement accuracy and regulatory audit readiness.
  • Certified for hygienic applications – Meets Sanitary 3-A and EHEDG (European Hygienic Engineering & Design Group) standards.
  • It comes with Ex-certified product versions for hazardous areas.

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