DuPont™ Kalrez® 6221

In the pharmaceutical, biotechnology, and cosmetics industries, manufacturing equipment must meet the highest standards of hygiene, safety, and sterilization. Pumps, valves, and process systems in direct contact with products require sealing materials that can withstand harsh chemicals, high temperatures, and ensure absolute puritythroughout operation.

To meet these stringent requirements, DuPont™ Kalrez® 6221 was developed — a perfluoroelastomer (FFKM) O-ring specifically designed for CIP (Clean-in-Place) and SIP (Sterilization-in-Place) applications in high-purity environments such as pharmaceutical and food production facilities.

The Challenge in CIP/SIP Operations

In hygienic and sterile production systems, sealing components must comply with strict international standards, including:

• FDA, GMP, and 3A-Sanitary requirements

• Compatibility with CIP and SIP cleaning cycles

• Compliance with DIN EN 12462 biotechnology standards (Europe)

• High performance under temperatures up to 160°C and exposure to aggressive cleaning agents

• Ultra-low extractables to minimize contamination risks

The Kalrez® 6221 Solution

Kalrez® 6221 is a high-performance perfluoroelastomer (FFKM) material engineered by DuPont™ for ultra-clean sealing applications.
Its outstanding chemical resistance and thermal stability allow it to maintain sealing integrity during repeated CIP/SIP cycles, significantly reducing the risk of leakage, contamination, and seal failure.

Key Features of Kalrez® 6221

✅ FDA & USP Class VI Certified
Approved for repeated use in direct food and pharmaceutical contact applications.

✅ Ultra-Low Extractables for Maximum Purity
Extractable levels below 0.2 mg/in², comparable to PTFE — ideal for ultra-pure and aseptic processes.

✅ Superior Chemical and Heat Resistance
Maintains elasticity and sealing performance in aggressive cleaning cycles, high-temperature steam, and chemical exposure.

✅ Smooth Surface – Designed for Hygienic Systems
Polished surface finish enables seamless integration with stainless steel components in hygienic design systems.

Customer Benefits

• Extended sealing life, reducing maintenance costs

• Enhanced product purity and biological safety throughout the production cycle

• Minimized downtime and improved operational efficiency

• Full compliance with international sanitary and quality standards

Typical Applications

• O-rings for CIP/SIP systems

• Pumps, valves, and sterile pipe fittings

• Mixing, filling, and packaging equipment in pharmaceutical and cosmetics manufacturing

• High-purity food and beverage production lines

Contact Filterfine Vietnam – Official Distributor of DuPont™ Kalrez®

Filterfine Vietnam is the authorized distributor of DuPont™ Kalrez® in Vietnam.
We provide high-performance FFKM sealing solutions and technical consulting services tailored for pharmaceutical, biotechnology, and food industry applications — ensuring reliability, purity, and compliance with global standards.

🌐 Website: https://filterfinevn.com
📞 Hotline: 0961.152.844
💬 Zalo OA: https://zalo.me/3662661132832477703